Non-alcoholic steatohepatitis

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Management

  • Weight loss is the mainstay of treatment, through calorie restriction with or without exercise
  • Patients should avoid heavy alcohol intake

Pharmacologic Therapy

  • Pioglitazone can be helpful
  • Can consider vitamin E 800 IU/day in NASH without diabetes or cirrhosis
  • Do not use metformin, and there is insufficient evidence for GLP-1 agonists
  • No recommendations yet for vitamin E in general NASH patients
  • No recommendations yet for omega-3 fatty acids

Further Reading