Antibiotic prophylaxis for open fractures
From IDWiki
Gustilo Classification
- Type I: open fracture with skin wound <1cm in length and clean
- Type II: open fracture with a laceration >1cm in length without extensive soft tissue damage, flaps, or avulsions
- Type III: open segmental fracture with >10cm wound with extensive soft tissue injury or a traumatic amputation
- IIIA: adequate soft tissue coverage
- All farm injuries and gunshots are automatically at least IIIA
- IIIB: significant soft tissue loss with exposed bone that requires soft tissue transfer to achieve coverage
- IIIC: associated vascular injury that requires repair for limb preservation
- Special categories:
- gunshot injuries
- any open fracture caused by a farm injury
- any open fracture with accompanying vascular injury requiring repair
- IIIA: adequate soft tissue coverage
Risk of Infection
- Type I: 0%
- Type II: 2%
- Type III: 6-44%
- Type IIIA: 2%
- Type IIIB: 11%
- Type IIIC: 20%
Management
- Don't forget tetanus!
- Antibiotic choice
- Cover gram-negatives as soon as possible after injury
- Add gram-negative coverage for type III fractures
- At HGH: cefazolin, tobramycin, and metronidazole
- Add high-dose penicillin to cover clostridium, in the presence of fecal contamination or farm-related injuries
- Fluoroquinolones should be avoided, if possible, due to slowing bone healing
- Duration
- Continue for 24 hours after wound closure
- If type III, continue for at least 72 hours post-injury if Type III