Monro-Kellie hypothesis

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Definition

  • Pressure-volume relationship between ICP, volume of CSF, blood, and brain tissue, and cerebral perfusion pressure
  • Fixed cranial vault with three compartments
    • Brain parenchyma
    • Cerebrospinal fluid (CSF)
    • Vasculature
      • Venous
      • Arterial
  • Compensation between the compartments can occur, up to a point
    • Autoregulation of blood vessel constriction/dilatation
    • Ventricles, which can compress the brain parenchyma
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