Hepatomegaly

Differential Diagnosis

• Hepatitis
  • Infections
    • Acute and chronic viral hepatitis
      • Acute Hepatitis A or B
      • Chronic Hepatitis B or C
    • Bacterial liver abscess
    • Parasitic infections
      • Fasciola hepatica
      • Clonorchis sinensis
      • Opisthorchis viverrini
    • Granulomatous hepatitis
  • Ischemia: ischemic hepatitis / shock liver
  • Toxins: alcoholic hepatitis
  • Steatosis
    • Alcoholic fatty liver disease
    • Nonalcoholic steatohepatitis
  • Medications: drug-induced liver injury (DILI)
  • Immune-mediated hepatitis: autoimmune hepatitis
  • Copper deposition: Wilson disease
• Storage disorders
  • Glycogen
    • Glycogen storage disorders
    • Diabetes mellitus
  • Lipid
    • Gaucher disease
    • Nonalcoholic steatohepatitis
  • Protein: alpha-1 antitrypsin deficiency
  • Iron: hemochromatosis
• Impaired venous outflow
  • Cardiac
    • Right heart failure
    • Constrictive pericarditis
  • Hepatic vein or IVC obstruction
    • Hepatic vein thrombosis
    • Inferior vena cava web
  • Intrahepatic
    • Sinusoidal obstruction syndrome
    • Peliosis hepatis
• Infiltrative disease
  • Benign primary liver sumours
    • Hemangiomas
    • Adenomas
    • Focal nodular hyperplasia
  • Malignant primary liver tumours
    • Hepatocellular carcinoma
    • Cholangiocarcinoma
    • Fibrolamellar carcinoma
    • Hemangioendothelioma
  • Metastases
    • Myeloma
    • Lumphoma
    • Leukemia
    • Metastatic solid tumours
• Biliary obstruction and cholestasis
  • Primary biliary cirrhosis
  • Primary sclerosing scholangitis
  • Biliary atresia
• Miscellaneous
  • Anatomic variations: Riedel's lobe
  • Cystic liver disease
    • Polycystic liver disease
    • Caroli's disease