Early goal-directed therapy

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  • Related to Surviving Sepsis campaign
  • Based on Rivers trial (2001)
  • Goals, in order:
    • CVP 8-12 mmHg, achieved with fluid boluses
    • MAP >65 mmHg, achieved with vasopressors if necessary
    • ScvO2 >70%, achieved with packed RBC transfusions and dobutamine if necessary
    • UOP >0.5 mL/kg/hr
  • Norepinephrine and vasopressin better than dobutamine