Cyanide toxicity

From IDWiki
Revision as of 01:17, 4 July 2020 by Maintenance script (talk | contribs) (Imported from text file)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Pathophysiology

  • Blocks the electron transport chain (ETC) complex 4, resulting in increased anaerobic metabolism

Clinical Presentation

  • Inhalation exposure with high lactate and venous hyperoxia
  • Headache
  • Nausea/vomiting
  • Tachycardia
  • Confusion
  • Seizures
  • Flushing more than cyanosis

Investigations

  • Laboratory
    • Lactate will be high

Management

  • Resuscitation
  • Decontamination
    • Hydroxycobalamin 5g IV x1, repeated if severe
    • Sodium thiosulfate 12.5g IV x1
    • Last-line: sodium nitrite
  • Co-exposures
Retrieved from "https://idwiki.org/index.php?title=Cyanide_toxicity&oldid=4159"
Powered by MediaWiki
Powered by Semantic MediaWiki