CCU drugs and concentrations
From IDWiki
| Drug | Standard Dilution | Concentrated Dilution | Usual Dose & Comments |
|---|---|---|---|
| Abciximab | LD: 2 mg/mL, undiluted MD: 9 mg/250 mL |
LD: 2 mg/mL, undiluted MD: 9 mg/250 mL |
LD: 0.25 mg/kg MD: 0.125 mcg/kg/min |
| Amiodarone (LD) | 150 mg/100 mL (P/C) | 300 mg/100 mL (C) | 150-300 mg over 10-30 min |
| Amiodarone (MD) | 450 mg/250 mL D5W only (P/C) | 900 mg/250 mL D5W only (C) | 900-1600 mg over 24h |
| Argatroban | 100 mg/100 mL (P) | 100 mg/100 mL (P) | MD: 0.5-2 mcg/kg/min Stable for 24h room temp or 96h fridge |
| Calcium gluconate | 1 g/100-1000 mL | Undiluted as 10% solution | Usual 1-2 g prn over 30-60min Usual max rate: 1g over 10min ACLS: 1g over 3min |
| Cisatracurium (Nimbex) |
100 mL/100 mL (P/C) | Undiluted in a Viaflex bag (P/C) | LD: 0.15-0.2 mg/kg over 30-60s MD: 1-3 mcg/kg/min |
| Dexmedetomidine (Precedex) |
200 mcg/50 mL NS only (P/C) | 200 mcg/50 mL NS only (P/C) | MD: 0.2-1.5 mcg/kg/h |
| Diltiazem | 100 mg/100 mL (P/C) | 100 mg/100 mL (P/C) | LD: 0.15-0.25 mg/kg over 2 min MD: 5-15 mg/h |
| Dobutamine | 250 mg/250 mL (P/C) | 500 mg/125 mL (C) or 500 mg/250 mL (P/C) |
Infusion 1-20mcg/kg/min |
| Dopamine | 400 mg/250 mL (P) | 800 mg/250 mL (C) | Infusion 1-20 mcg/kg/min |
| Enalaprilat | 0.625-1.25 mg/25-50 mL (P/C) | Undiluted (P/C) | Bolus: 0.625-1.25 mg over 5-10 min q6h |
| Epinephrine (1:1000) | 2 or 4 mg/250 mL (C) | 8 or 16 mg/250 mL (C) | Infusion: 0.02-0.35 mcg/kg/min |
| Eptifibatide (Integrellin) |
LD: 2 mg/mL vial (P) MD: 0.75 mg/mL vial (P) |
LD: 2 mg/mL vial (P) MD: 0.75 mg/mL vial (P) |
LD: 180 mcg/kg over 1-2 min |
| Esmolol | 2500 mg/250 mL (P/C) | 2500 mg/250 mL (P/C) | LD: 0.25-0.5 mg/kg over 1 min MD: 0.05-0.3 mg/kg/min |
| Fentanyl | 2000 mcg/100 mL (P/C) | Undiluted as 50 mcg/mL (P/C) | Bolus: 25-100 mcg MD: 25-200 mcg/h |
| Furosemide (Lasix) |
100 mg/100 mL (P/C) | 200 mg/100mL (P/C) undiluted (P/C) |
Bolus: 20-320 mg (max rate 4 mg/min) Infusion 1-30 mg/h |
| Protect in brown paper bag | |||
| Haloperidol (Haldol) |
100-250 mg/250 mL D5W only (P/C) | 100-250 mg/250 mL D5W only (P/C) | Bolus 2-10 mg MD: 0.04-0.15 mg/kg/h or 10-40 mg/h |
| Isoproterenol (Isuprel) |
2 mg/250 mL (P/C) | 4 mg/250 mL (P/C) | MD: 1-20 mcg/min |
| Insulin Regular | 50 u/250 mL (P/C) 25 u/250 mL (P/C) |
100 u/100 mL (P/C) 50 u/50 mL (P/C) |
|
| Labetalol (Trandate) |
200 mg/160 mL (P/C) | undiluted 5 mg/mL (P/C) | Bolus: 10-80 mg q10min MD: 0.125-2 mg/min |
| Lepirudin | Reconstitute 50 mg vial 1 mL SWFI or NS | Reconstitute 50 mg vial 1 mL SWFI or NS | LD: 0.07 mg/kg |
| LD: dilute vial into 10 mL syringe | LD: dilute vial into 10 mL syringe | MD: 0.05-0.15 mg/kg/h | |
| MD: two vials to either 250 mL or 500 mL bag | MD: two vials to either 250 mL or 500 mL bag | LD and MD based on CrCl | |
| Lidocaine | Bolus: 20 mg/mL undiluted Infusion: 250-500 mg/250 mL |
Infusion 1000 mg/250 mL | Bolus 1-1.5 mg/kg Infusion 1-4 mg/min |
| Lorazepam (Ativan) |
Intermittent: 4 mg/20-50 mL (D5W only) Continuous: 25 mg/250 mL (D5W only) |
Intermittent: 4 mg/20-50 mL (D5W only) Continuous: 25 mg/250 mL (D5W only) |
LD: 0.5-10 mg over 1-2 min MD: 0.5-20 mg/h |
| Magnesium sulfate | 2 g/50-100 mL | Maximum 200 mg/mL (i.e. 2 g/10 mL) | Bolus 1-6 g prn Max rate 150 mg/min (1g over 6 min) ACLS: higher rates |
| Metoprolol | Push: 2.5-5 mg over 1-2 min Intermittent: 2.5-15 mg/50 mL over 15 min Continuous: 30 mg/100 mL (P/C) |
Push: 2.5-5 mg over 1-2 min Intermittent: 2.5-15 mg/50 mL over 15 min Continuous: 30 mg/100 mL (P/C) |
Bolus 2.5-5 mg q4-6h Infusion 1-5 mg/h |
| Midazolam (Versed) |
50-100 mg/50-100 mL (P/C) | Undiluted 5 mg/mL in Viaflex bag | LD: 0.5-10 mg over 1-2 min MD: 1-10 mg/h |
| Milrinone | 20 mg/100 mL (P/C) | 40 mg/100 mL (P/C) | LD: 50 mcg/kg over 10 min MD: 0.125-0.75 mcg/kg/min Dose adjusted for renal dysfunction |
| Morphine | 100 mg/100 mL (P/C) | 5-10 mg/mL (P/C) | LD: 0.5-10 mg over 1-2 min MD: 0.5-20 mg/h |
| Nitroglycerin | 50 mg/250 mL in D5W (P/C) | 100 mg/250 mL in D5W (P/C) | 13-400 mcg/min Use glass bottle & non-PVC or low-sorb tubing |
| Nitroprusside (Nipride) |
50 mg/250 mL in D5W (P/C) | 100 mg/250 mL in D5W (P/C) | 0.25-10 mcg/kg/min CHF range: 0.25-3 mcg/kg/min Protect from light in paper bag |
| Norepinephrine (Levophed) |
4 mg/250 mL (C) | 8-16 mg/250 mL (C) | 0.02-0.35 mcg/kg/min |
| Pancuronium | 50 mg/50 mL (P/C) | Undiluted as 2 mg/mL (P/C) | LD: 0.04-0.1 mg/kg MD: 0.02-0.04 mg/kg q1-4h |
| Phenylephrine | 50 mg/250 mL (C) | 200 mg/250 mL (C) | LD: 0.1-0.2 mg over 2 min MD: 0.3-3 mcg/kg/min |
| Propofol | 10 mg/mL premixed bottle (P/C) | 10 mg/mL premixed bottle (P/C) | MD: 20-200 mg/h |
| Potassium chloride | 20-40 mmol/L (P) | 40 mmol/100 mL over 90 min (C) | Routine: 10 mmol/h Severe hypoK: 20 mmol/h Emergency: 40 mmol/h |
| Potassium phosphate (3 mmol PO |
3-15 mmol PO |
15-30 mmol PO |
3-15 mmol PO |
| Procainamide | 1000 mg/250 mL (P/C) | 2000 mg/250 mL (P/C) | LD: 500-1000 mg (max 25 mg/min) MD: 1-6 mg/min |
| Sodium phosphate (3 mmol PO |
3-15 mmol PO |
15-30 mmol PO |
3-15 mmol PO |
| Tirofiban | 12.5 mg/250 mL premixed bag (P) | 12.5 mg/250 mL premixed bag (P) | LD: 0.4 mcg/kg/min (for 30 min) MD: 0.1 mcg/kg/min |
| Vasopressin | 40 u/100 mL (C) | 100 u/100 mL (C) | 0.4-6 u/h ACLS: 40 u IV push |
| Vecuronium | 20 mg/100 mL (P/C) | 100 mg/100 mL (P/C) | LD: 0.08-0.1 mg/kg MD: 0.6-1.8 mcg/kg/min |
| LD: loading dose |
MD: maintenance dose
P/C: peripheral/central
