Fluconazole

Fluconazole

Classification

• Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of Candida

Indications

• Fungal infections

Monitoring

• ECG for QT prolongation
• Liver enzymes for hepatitis

Pharmacokinetics

• Good oral bioavailability
• CNS penetration

Side Effects

• Best side effect profiles of the antifungals
• Before starting, check:
  • Liver enzymes as baseline
  • Creatinine (requires renal dosing)
  • EKG (QT prolongation)
• Beware drug-drug interactions, especially with new DOACs