Acute generalized exanthematous pustulosis

• Also known as a pustular drug eruption or toxic pustuloderma
• Typically triggered by medications
  • Antibiotics (especially β-lactams) are most common trigger by far, followed by PPIs, NSAIDs, and herbal medicine
• Characteristic rash is diffuse, erythematous, with many pinpoint pustules
  • Typically starts in face or intertriginous areas, then spreads centrally
  • Can involve palms and soles but not mucosa
  • May be followed by desquamation
• Can also have systemic symptoms
• May have mild liver enzyme abnormalities