Pediatric dosing of antimicrobials

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Antibiotics

Penicillins

Drug Indication Age Weight Usual dose
Penicillin G IV/IM moderate to severe infections 100,000 to 400,000 U/kg/day split q4-6h (max 24 MU/day)
meningitis 400,000 U/kg/day split q4h (max 24 MU/day)
Penicillin VK PO mild to moderate infections 25-50 mg/kg/day split q8-12h
rheumatic fever (treatment) ≤ 27 kg 300 mg PO bid x10 days
> 27 kg 600 mg PO bid x 10 days
rheumatic fever (prophylaxis) > 5 years 300 mg PO bid
asplenia (prophylaxis) 6 months to 5 years 150 mg PO bid
> 5 years 300 mg PO bid