Neonatal HBV

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  • If mother has hepatitis B, or her status is unknown, then consider post-exposure prophylaxis with hepatitis B immune globulin and hepatitis B vaccine given within 12 hours of life
    • Vaccine prevents about 90% of infections, with HBIG adding a bit more
    • HBIG can be given up to 7 days of life but is most effective when given earlier
  • Also see article on neonatal HIV