HIV-hepatitis C coinfection
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HIV-Hepatitis C (HCV) coinfection
Principles
- Confirm both diagnoses, including ensuring HCV RNA is still positive 6 months after first measured
- Treat the HIV first, using any first-line regimen
- Treat the HIV for at least 2 weeks before starting HCV treatment
Regimens
- Consult HEP Drug Interactions checker
- Be careful with Harvoni, which can increase levels of tenofovir, especially when GFR <60 mL/min
Further Reading
- "Considerations for Antiretroviral Use in Patients with Coinfections", in Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. AIDSinfo.
- "Patients With HIV/HCV Coinfection", in HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C. IDSA & AASLD.
