HSV in pregnancy

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  • Infection with herpes simplex virus during pregnancy
  • Highest risk for transmission is perinatal primary infection
Risk of neonatal acquisition of HSV based on maternal serostatus
Serology Neonatal HSV per 100,000 births
Negative 54
HSV-1 only 26
HSV-2 only 35
HSV-1 + HSV-2 12
HSV-2 ± HSV-1 22
  • If acquired during pregnancy, HSV can cause spontaneous abortion and should be treated for 7 to 10 days
  • If HSV-2-positive, then if there are lesions or PCR-positivity at time of labour, could consider Cesarean section