Drug-resistant tuberculosis
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Multi-drug-resistant tuberculosis (MDR-TB)
Definition
- [Tuberculosis](Tuberculosis (TB).md) infection that is resistant to both first-line drugs, isoniazid and rifampin
Management
- 8 months of an intensive four-drug regimen that includes any four drugs to which it is susceptible, in order of preference:
- Any first-line agents to which it is still susceptible
- A fluoroquinolone (except ciprofloxacin)
- An injectable: kanamycin, or other parenteral agent
- Other second-line agents, starting with ethionamide
- Followed by 12 months of a less intensive regimen (at least three effective drugs), for a total of at least 20 months
