Bacterial meningitis (IDSA 2004)

Table 4: Empiric Treatment

Population	Common pathogens	Antimicrobial therapy
Age
<1 month	GBS, E.coli, Listeria, Klebsiella	amp + cefotax, or amp + AG
1-23 months	S.pneumo, N.mening, GBS, H.flu, E.coli	vanco + 3G ceph
2-50 years	N.mening, S.pneumo	vanco + 3G ceph
>50 years	S.pneumo, N.mining, Listeria, GNBs	vanco + 3G ceph + amp
Head trauma
Basilar skull fracture	S.pneumo, H.flu, GAS	vanco + 3G ceph
Penetrating trauma	Staph.aureus, CoNS, GNBs	vanco + cefep, or vanco + ceftaz, or vanco + mero
Post-neurosurgery	GNBs, Staph.aureus, CoNS	vanco + cefep, or vanco + ceftaz, or vanco + mero
CSF shunt	CoNS, Staph,aureus, GNBs, P.acnes	vanco + cefep, or vanco + ceftaz, or vanco + mero