Cefazolin
From IDWiki
Background
Clinical Breakpoints
| Species | ECV (μg/mL) | Breakpoints (μg/mL) | Breakpoints (mm) | ||||
|---|---|---|---|---|---|---|---|
| S | I | R | S | I | R | ||
| Enterobacteriaceae (systemic) | ≤2 | 4 | ≥8 | ||||
| Enterobacteriaceae (urinary) | ≤16 | ≥32 | |||||
Dosing
- Low dose (for UTI or uncomplicated soft tissue infection): 1 g IV
- Standard dose: 2 h IV q8h
- High dose (for critical illness and IE): 2 g IV q6h
Renal Dosing
| eGFR (mL/min) | Standard Dose | High Dose |
|---|---|---|
| >40 | 2 g IV q8h | 2 g IV q6h |
| 20-40 | 2 g IV q12h | 2 g IV q12h |
| <20 | 1 g IV q24h | 1 g IV q24h |
| CRRT | 2 h IV q12h | 2 h IV q12h |
