Imipenem-cilastatin

Background

• Broad-spectrum carbapenem
• Spectrum includes enterococci and Acinetobacter
  • Compared to meropenem, imipenem is more active against Acinetobacter and enterococci, and possibly less active against Pseudomonas

Dosing

• Routine: 500 mg IV every 6 hours
• Cystitis: 250-500 mg IV every 6 hours
• Severe or pseudomonal infections: consider up to 1 g IV every 6 to 8 hours