Parkinson-plus syndrome
From IDWiki
- Group of neurodegenerative diseases similar to Parkinson disease
| Lewy-body disease | Multiple system atrophy | Corticobasal degeneration | Progressive supranuclear palsy | |
|---|---|---|---|---|
| Epidemiology | Common; 30% of all dementia cases | 2 to 5 cases per 100,000, mean onset 54 years | 5 to 7 per 100,000, mean onset early 60s | 3 to 7 per 100,000 |
| Clinical manifestations | Deficits in attention, cognition, visuospatial function, with visual hallucinations and sleep movement disorders, falls, autonomic dysfunction | Akinetic-rigid parkinsonism with cerebellar ataxia, autonomic failure, urogenital dysfunction, and pyramidal signs | Asymmetric movement disorder with akinesia and rigidity, myoclonus, dystonia, apraxia | Gait dysfunction with frequent falls, and a supranuclear palsy (unable to move eyes vertically), axial rigidity |
