Fidaxomicin
From IDWiki
- Antibiotics indicated for Clostridioides difficile infection
- Standard dose is 200 mg p.o. twice daily for 10 days
- Pulse-tapered regimen is 200 mg once daily for 7 days followed by 200 mg fidaxomicin every other day for the remaining 13 doses1
- In Ontario, EAP criteria for approval through the telephone request service includes: third or subsequent episode treated with vancomycin within 6 months; treatment failure despite at least 7 days of vancomycin; allergy to oral vancomycin; severe adverse reaction or intolerance to oral vancomycin
References
- ^ Andrew M Skinner, Xing Tan, Benjamin D Sirbu, Larry H Danziger, Dale N Gerding, Stuart Johnson. A Tapered-pulsed Fidaxomicin Regimen Following Treatment in Patients With Multiple Clostridioides difficile Infection Recurrences. Clinical Infectious Diseases. 2021;73(6):1107-1109. doi:10.1093/cid/ciab233.
