Hypogammaglobulinemia
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Revision as of 11:57, 16 October 2024 by Aidan (talk | contribs) (Created page with "== Etiologies == * Primary hypogammaglobulinemia ** Common variable immunodeficiency (CVID) ** IgG subclass deficiencies, including IgG1, IgG2 ** Hyper-IgM syndrome ** ADA deficiency ** Hypomorphic recombination-activating gene mutation ** Artemis defect * Secondary hypogammaglobulinemia ** Decreased production *** Medications, including B-cell depletion (rituximab, CAR-T, BiTE), corticosteroids, antiepileptic medications, and chemotherapy *** Malign...")
Etiologies
- Primary hypogammaglobulinemia
- Common variable immunodeficiency (CVID)
- IgG subclass deficiencies, including IgG1, IgG2
- Hyper-IgM syndrome
- ADA deficiency
- Hypomorphic recombination-activating gene mutation
- Artemis defect
- Secondary hypogammaglobulinemia
- Decreased production
- Medications, including B-cell depletion (rituximab, CAR-T, BiTE), corticosteroids, antiepileptic medications, and chemotherapy
- Malignancy, including CLL, lymphoma, multiple myeloma, Waldenström macroglobulinemia, and thymoma (Good syndrome)
- Increased loss: protein-losing enteropathy, nephrotic syndrome, burns, trauma
- Decreased production
