Bispecific T-cell engager

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Background

  • Recombinant proteins that bind to two different antigens, one of which activates T cells and the other binds a cancer target
  • Used in treating some hematologic malignancies

Safety

Adverse Effects

Screening

  • Consider baseline HIV, EBV, CMV, hepatitis B, and hepatitis C serologies

Antimicrobial Prophylaxis

  • Unclear role for antibiotics and antifungals, in general
  • Likely PJP and VZV prophylaxis for duration of treatment