Clofazimine

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Revision as of 13:32, 24 August 2023 by Aidan (talk | contribs) (Created page with "== Background == * Antibiotic * Indicated for leprosy and non-tuberculous mycobacteria * Has never been studied in an RCT * Mechanism of action is postulated to be redox cycling and memrane destabilization and dysfunction == Safety == === Adverse Effects === * Skin darkening: exposure-related, onset is gradual. Not permanent, will slowly resolve after stopping the drug. * Dry skin and generalized pruritus * QT prolongation and possibly torsades de pointes...")

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Background

Antibiotic
Indicated for leprosy and non-tuberculous mycobacteria
Has never been studied in an RCT
Mechanism of action is postulated to be redox cycling and memrane destabilization and dysfunction

Safety

Adverse Effects

Skin darkening: exposure-related, onset is gradual. Not permanent, will slowly resolve after stopping the drug.
Dry skin and generalized pruritus
QT prolongation and possibly torsades de pointes
Crystal deposition in liver, spleen, and lymph nodes, usually presenting as worsening abdominal pain

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Antibiotics