Amoxicillin-clavulanic acid

Dosing

• Oral: 500 mg/125 mg p.o. three times daily, or 875 mg/125 mg p.o. twice daily
• Intravenous:
  • Usual dose: 1 g (1000 mg/ 200 mg) IV every 8 hours
  • High dose: 2 g (2000 mg/ 200 mg) IV every 8 to 12 hours

Renal Dosing

CrCl (mL/min)	Dose
Oral
>30	875/125 mg p.o. q12h
10-29	500/125 mg p.o. q12h
<10	500/125 mg p.o. q24h
Hemodialysis	500/125 mg p.o. q24h (given after dialysis on dialysis days)
Peritoneal dialysis	250/125 mg p.o. q12h
CRRT	Usual dose
Intravenous
>30	1 g IV q8h
10-29	1 g IV followed by 500 mg IV q12h
<10	1 g IV followed by 500 mg IV q24h
Hemodialysis	1 g IV followed by 500 mg IV q24h (given after dialysis on dialysis days)