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- 21:00, 23 January 2025 Aidan talk contribs created page Li-Fraumeni syndrome (Created page with "* Genetic autosomal dominant hereditary disorder that increases risk of various malignancies * Also called SBLA (sarcoma, breast, leukemia, and adrenal) syndrome * Caused by mutations in the ''TP53'' tumour suppressor gene * Associated cancers: ** Early-onset breast cancer (25%) ** Soft-tissue sarcoma (20%) ** Bone sarcoma (15%) ** Brain tumours, particularly glioblastomas (13%) ** Others: leukemia, lymphoma, and adrenal carcinoma Category:Oncology")
