Β-lactamases
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Β-lactamases /
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Extended-spectrum beta-lactamase (ESBL)
Definition
- Bacteria containing a plasmid that codes for an extended-spectrum beta-lactamase (ESBL)
- Most common with Escherichia coli and Klebsiella
Classification
- Class A
- Constitutively expressed plasmid
- Most common ESBL in Gram-negative bacteria
- Resistance to 2nd and 3rd generation cephalosporins
- Common in E. coli, Klebsiella, and Proteus spp.
- Class C
- Inducible AmpC gene present in the genome
- Common in Citrobacter, Serratia, and Enterobacter
Management
- Antibiotic therapy tailored to the resistance pattern
- Carbapenems, aminoglycosides, fluoroquinolones, and Septra typically work well
References
- ^ R. Cantón, M.I. Morosini, O. Martin, S. de la Maza, E. Gomez G. de la Pedrosa. IRT and CMT β-lactamases and inhibitor resistance. Clinical Microbiology and Infection. 2008;14:53-62. doi:10.1111/j.1469-0691.2007.01849.x.
