Chronic fatigue syndrome

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Definition

  • Syndrome of chronic fatigue of unknown etiology
  • Also called myalgic encephalomyelitis

CDC Diagnostic Criteria

  • Severe fatigue for longer than six months, and at least four of the following symptoms:
    • Headache of new type, pattern, or severity
    • Multijoint pain without swelling or erythema
    • Muscle pain
    • Postexertional malaise for longer than 24 hours
    • Significant impairment in short-term memory or concentration
    • Sore throat
    • Tender lymph nodes
    • Unrefreshing sleep

Investigations

  • Urinalysis, CBC, lytes, glucose, creatinine
  • TSH, CRP, phosphorous (not sure why)
  • Can also do antiendomysial antibodies for Celiac disease, rheumatoid factor, and ANA

Management

  • Rule out other causes of fatigue
  • Treat comorbidities
    • Sleep disturbance
    • Depression
    • Pain
  • Cognitive behavioural therapy
  • Graded exercise therapy