Haff syndrome

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Background

Epidemiology

  • Associated with ingestion of specific fish: crayfish, buffalo fish, burbot, eel, pike, arabaiana, and yellowtail amberjack
  • Occurs worldwide (fish species varies)

Clinical Manifestations

  • Occurs within 24 hours of ingestion
  • Unexplained rhabdomyolysis with sudden, extreme muscular rigidity, diffuse myalgia, chest pain, shortness of breath, full-body numbness and weakness, and coffee-colored urine
  • Elevated serum creatine kinase, myoglobin, transaminases, and lactate