Cerebrospinal fluid leak

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Background

  • CSF leaks are associated with a high risk of meningitis (10-25%, depending on etiology and chronicity)

Management

  • Current IDSA guidelines recommend:
    • No routine prophylactic antibiotic in patients with basilar skull fractures and CSF leak
    • Surgical repair if leak lasts more than 7 days
    • Pneumococcal vaccination

Further Reading

  • Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis. 2017;64(6):e34-e65. doi: 10.1093/cid/ciw861