Cyclic lipopeptide antibiotic that is active against Gram-positive bacteria
Mechanism of Action
Mechanism of action is to depolarize the cell membrane
Pharmacokinetics and Pharmacodynamics
Bactericidal
Distributes well into soft tissues and musculoskeletal system, as well as urine
Poor CNS penetration
Good lung penetration, but is inactivated by lung surfactant and should not be used to treat pneumonia
References
^S. Piva, Antonello Di Paolo, Laura Galeotti, Francesco Ceccherini, Francesco Cordoni, Liana Signorini, Tommaso Togni, Amedeo De Nicolò, Frank A. Rasulo, Nazzareno Fagoni, N. Latronico, Antonio D’Avolio. Daptomycin Plasma and CSF Levels in Patients with Healthcare-Associated Meningitis. Neurocritical Care. 2019;31(1):116-124. doi:10.1007/s12028-018-0657-y.
