Vaccination after hematopoietic stem cell transplantation

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  • Following hematopoietic stem cell transplantation, the new, naive immune system requires essentially all (allogeneic) or most (autologous) routine immunizations
  • Most live vaccines can be given after 24 months, including univalent varicella, MMR, and yellow fever faccines
    • MMRV, rotavirus, smallpox, oral poliovirus are all contraindicated
    • Must not be experiencing graft-versus-host disease or undergoing significant immunosuppression
      • No corticosteroids or other immunosuppressnats for at least 3 months
    • Must also be assessed by their primary team as having normal immunity
  • Close contacts should also ensure vaccinations are up to date