- If mother has hepatitis B, or her status is unknown, then consider post-exposure prophylaxis with hepatitis B immune globulin and hepatitis B vaccine given within 12 hours of life
- Vaccine prevents about 90% of infections, with HBIG adding a bit more
- HBIG can be given up to 7 days of life but is most effective when given earlier
- Also see article on neonatal HIV
