Microangiopathic hemolytic anemia

Differential Diagnosis

• Primary/thrombotic microangiopathies (TMA)
  • Thrombotic thrombocytopenic purpura (TTP)
    • Congenital (Upshaw-Shulman)
    • Acquired
  • Hemolytic uremic syndrome (HUS)
    • Typical (Shiga-producing E. coli)
    • Atypical hemolytic uremic syndrome (aHUS) (congenital complement-overactivation)
• Secondary
  • Antiphospholid syndrome
  • Malignant hypertension
  • Lymphomas and solid tumours
  • Scleroderma crisis
  • Drug-associated: calcineurin inhibitors, quiinine, ticlopidine
  • Vasculitis
  • Infections: HIV, influenza, EBV, parvovirus
  • Diffuse intravascular coagulation (DIC)
  • HELLP syndrome