Oseltamivir

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Background

Mechanism of Action

  • Inhibits viral neuraminidase

Dose

Adults

  • Influenza (treatment): 75 mg PO bid
  • Influenza (prophylaxis): 75 mg PO daily

Renal Dosing

Indication CrCl >60 CrCl >30 to 60 mL/min CrCl >10 to 30 mL/min IHD
Influenza (treatment) Usual dose 30 mg PO bid 30 mg PO daily 30 (low-flux) to 75 (high-flux) mg PO after dialysis
Influenza (prophylaxis) Usual dose 30 mg PO daily 30 mg PO every other day 30 mg PO after every other dialysis