Peripheral neuropathy

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Differential Diagnosis

Mononeuropathy
- Compression/injury
- Infiltration
- Mononeuritis
Mononeuritis multiplex
- Vasculitis
- Diabetes
Polyneuropathy
- Axonal injury
  - Neoplasm: carcinoma, lymphoma, MGUS
  - Infection: sepsis, chronic HIV, Lyme disease
  - Metabolic: diabetes, uremia
  - Vitamin deficiency: malabsorption
  - Drugs: cisplatin, taxanes, vincristine, isoniazid, nucleoside analogues
- Demyelinating
  - Guillain-Barre syndrome
  - Neoplasm: carcinoma, lymphoma, MGUS-IgM
  - Drugs: taxanes
  - Chronic inflammatory demyelinating polyradiculoneuropaty (CIDP)
Amyloid polyneuropathy
Charcot-Marie-Tooth disease
Critical illness neuropathy
Hypothyroidism

Investigations

Labs
- CBC, lytes, creatinine, glucose, ESR/CRP, SPEP, vitamin B12, ANA, TSH, urinalysis
- Based on presentation
  - EMG and nerve conduction
  - Nerve or muscle biopsy
  - LP
  - Lyme serology, HIV test, RPR/VDRL, HBV/HCV serology

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Neurology