Recurrent meningitis

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Differential Diagnosis

  • Immune defects
    • Asplenia
    • Hypogammaglobulinemia
    • Complement deficiences
  • Parameningeal focus of infection
  • Structural abnormalities
    • Post-neurosurgery
    • CSF leak or fistula
    • Dermal sinuses
    • Epidermoid cysts
    • Craniopharyngioma
  • Drugs
    • Septra
    • NSAIDs
    • IVIg
    • OKT3
    • Phenytoin
  • Infections
    • HSV (Mollaret's disease)
  • Inflammatory
    • SLE
    • Behcet's

Specific Patients

Terminal Complement Deficiency

  • Prone to recurrent Neisseria infections

Hypogammaglobulinemia