Post-transplant acute limbic encephalitis

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  • Limbic encephalitis syndrome following hematopoietic stem cell transplantation

Background

Clinical Presentation

  • Onset 2 weeks to 2 months after transplant
  • Presents with confusion, amnesia, hallucinations
  • Can cause seizures
  • Hyponatremia is common

Management

  • Treat seizures with antiepileptic medications
  • Treat any possible concomitant risk factors such as hyponytremia
  • Antivirals: acyclovir, ganciclovir, or foscarnet for 10 days to 4 weeks