Screening before prolonged immunosuppressive therapy

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ID screening for prolonged immunosuppressive therapy

  • Tuberculosis
    • Screen if pred 15mg daily for 1+ month
    • TB skin test (false positive if BCG and needs a 48h repeat)
      • Still useful to test up after up to two weeks of ≤20mg daily prednisone
    • IGRA (expensive)
  • Hepatitis B
    • Screen if >7.5mg prednisone daily
    • Treat if HbSag positive or if HbCAb and HBV-DNA positive
    • Prophylaxis with lemivudine for 6 months after the immune suppression is done
  • Strongyloides
    • Screen with serology if has ever travelled to an endemic country