Myasthenia gravis
From IDWiki
Definition
- A autoimmune disorder of the motor endplate that is associated with thymomas and causes a syndrome of weakness that worsens with repeated movements
- Can also present with predominantly bulbar involvement, or simple ocular involvement
Clinical Manifestations
- History
- Signs & Symptoms
- Ptosis worse than baseline
- Abnormal or fatiguable extraocular movements
- Dysarthria
- Neck flexion and extension (tests C3-4 that also innervates the diaphragm)
- Decreased duration of limb raiding
Management
- Acute
- Monitor FVC, MIPS, and MEPS
- Can approximate FVC by counting the duration of exhilation
- Monitor FVC, MIPS, and MEPS
- Chronic
References
- ^ Shuja Sheikh, Usman Alvi, Betty Soliven, Kourosh Rezania. Drugs That Induce or Cause Deterioration of Myasthenia Gravis: An Update. Journal of Clinical Medicine. 2021;10(7):1537. doi:10.3390/jcm10071537.
