Fungal osteomyelitis
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Revision as of 17:00, 3 January 2024 by Aidan (talk | contribs) (Created page with "== Background == === Microbiology === * Causative organisms include: Candida and other yeasts, Aspergillus, Mucorales, dematiaceous molds, non-''Aspergillus'' hyaline molds, and endemic mycoses (Histoplasma, Blastomyces, and Coccidioides) == Clinical Manifestations == * Candidal osteomyelitis and septic arthritis has more hematogenous spread than other causes * Hyaline molds, including Aspergillosis, are commonly after trau...")
Background
Microbiology
- Causative organisms include: Candida and other yeasts, Aspergillus, Mucorales, dematiaceous molds, non-Aspergillus hyaline molds, and endemic mycoses (Histoplasma, Blastomyces, and Coccidioides)
Clinical Manifestations
- Candidal osteomyelitis and septic arthritis has more hematogenous spread than other causes
- Hyaline molds, including Aspergillosis, are commonly after traumatic inoculation
Management
- Duration, regardless of causative organism, is typically in the range of a few months to a few years[1]
- Candida: median 90 days (range 7 to 720 days)
- Aspergillus: median 90 days (range 10 to 772 days)
- Dimorphic fungi: median 180 days (range 70 to 365 days)
- Mucormycosis: median 45 days (range 5 to 573 days)
- Other non-Aspergillus molds: median 115 days (range 5 to 730 dats)
Further Reading
- Osteoarticular mycoses. Clin Microbiol Rev. 2022;35(4):e0008619. doi: 10.1128/cmr.00086-19
- ↑ Gamaletsou MN, Rammaert B, Brause B, Bueno MA, Dadwal SS, Henry MW, Katragkou A, Kontoyiannis DP, McCarthy MW, Miller AO, Moriyama B, Pana ZD, Petraitiene R, Petraitis V, Roilides E, Sarkis JP, Simitsopoulou M, Sipsas NV, Taj-Aldeen SJ, Zeller V, Lortholary O, Walsh TJ; International Consortium for Osteoarticular Mycoses. Osteoarticular Mycoses. Clin Microbiol Rev. 2022 Dec 21;35(4):e0008619. doi: 10.1128/cmr.00086-19. Epub 2022 Nov 30. PMID: 36448782; PMCID: PMC9769674.
References
- ^ Maria N. Gamaletsou, Blandine Rammaert, Barry Brause, Marimelle A. Bueno, Sanjeet S. Dadwal, Michael W. Henry, Aspasia Katragkou, Dimitrios P. Kontoyiannis, Matthew W. McCarthy, Andy O. Miller, Brad Moriyama, Zoi Dorothea Pana, Ruta Petraitiene, Vidmantas Petraitis, Emmanuel Roilides, Jean-Pierre Sarkis, Maria Simitsopoulou, Nikolaos V. Sipsas, Saad J. Taj-Aldeen, Valérie Zeller, Olivier Lortholary, Thomas J. Walsh. Osteoarticular Mycoses. Clinical Microbiology Reviews. 2022;35(4). doi:10.1128/cmr.00086-19.
