Cytokine release syndrome
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Revision as of 01:44, 26 March 2024 by Aidan (talk | contribs) (Created page with "== Background == * Adverse effect of CAR-T and BiTE therapies == Clinical Manifestations == * Fever, hypotension, tachypnea, tachycardia, headache, rash, dyspnea, hypoxemia == ASTCT CRS GradingCiteRef::lee2019as == {| class="wikitable" !Parameter !Grade 1 !Grade 1 !Grade 3 !Grade 4 |- |Fever |≥38ºC |≥38ºC |≥38ºC |≥38ºC |- | colspan="5" |with |- |Hypotension |— |Not on vasopressors |One vasopressor ± vasopressin |Multiple vasopressors |- | c...")
Background
Clinical Manifestations
- Fever, hypotension, tachypnea, tachycardia, headache, rash, dyspnea, hypoxemia
ASTCT CRS Grading1
| Parameter | Grade 1 | Grade 1 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Fever | ≥38ºC | ≥38ºC | ≥38ºC | ≥38ºC |
| with | ||||
| Hypotension | — | Not on vasopressors | One vasopressor ± vasopressin | Multiple vasopressors |
| and/or | ||||
| Hypoxia | — | Low-flow nasal cannula | High-flow nasal cannula, facemask, nonrebreather mask, Venturi mask | Positive-pressure ventilation (non-invasive or invasive) |
References
- ^ Daniel W. Lee, Bianca D. Santomasso, Frederick L. Locke, Armin Ghobadi, Cameron J. Turtle, Jennifer N. Brudno, Marcela V. Maus, Jae H. Park, Elena Mead, Steven Pavletic, William Y. Go, Lamis Eldjerou, Rebecca A. Gardner, Noelle Frey, Kevin J. Curran, Karl Peggs, Marcelo Pasquini, John F. DiPersio, Marcel R.M. van den Brink, Krishna V. Komanduri, Stephan A. Grupp, Sattva S. Neelapu. ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells. Biology of Blood and Marrow Transplantation. 2019;25(4):625-638. doi:10.1016/j.bbmt.2018.12.758.
