Clofazimine
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Revision as of 13:32, 24 August 2023 by Aidan (talk | contribs) (Created page with "== Background == * Antibiotic * Indicated for leprosy and non-tuberculous mycobacteria * Has never been studied in an RCT * Mechanism of action is postulated to be redox cycling and memrane destabilization and dysfunction == Safety == === Adverse Effects === * Skin darkening: exposure-related, onset is gradual. Not permanent, will slowly resolve after stopping the drug. * Dry skin and generalized pruritus * QT prolongation and possibly torsades de pointes...")
Background
- Antibiotic
- Indicated for leprosy and non-tuberculous mycobacteria
- Has never been studied in an RCT
- Mechanism of action is postulated to be redox cycling and memrane destabilization and dysfunction
Safety
Adverse Effects
- Skin darkening: exposure-related, onset is gradual. Not permanent, will slowly resolve after stopping the drug.
- Dry skin and generalized pruritus
- QT prolongation and possibly torsades de pointes
- Crystal deposition in liver, spleen, and lymph nodes, usually presenting as worsening abdominal pain
