Burkholderia cepacia complex

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Burkholderia cepacia complex /
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Background

  • Gram-negative bacillus
  • Classified into nine genomovars (phenotypically similar but genotypically distinct)
  • Multiple mechanisms of resistance:
    • β-lactamases
    • RND efflux pumps
    • Altered LPS conferring polymixin resistance
    • Gyrase mutations conferring fluoroquinolone resistance

Clinical Manifestations

Management