Nutritionally variant streptococci

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Background

  • Require pyridoxine (vitamin B6) supplementation to group
  • Also called pyridoxal-dependent or stalliting streptococci

Organisms

Clinical Manifestations

Management

  • Susceptibilities shown below are from several studies123
Antibiotic Abiotrophia defectiva Granulicatella adiacens Granulicatella elegans
Penicillin 14 to 57% 34 to 82% 80 to 100%
Ampicillin 86% 100% 100%
Piperacillin 0% 53% 100%
Cefazolin 29% 88% 100%
Ceftriaxone 92 to 100% 22 to 76% 90 to 100%
Ceftazidime 0% 0% 50%
Imipenem 100% 100% 100%
Meropenem 72 to 81% 87 to 95% 91%
Gentamicin 0% 0% 0%
Ciprofloxacin 100% 18% 17%
Levofloxacin 100% 97 to 100% 92%
Minocycline 57% 94% 100%
Vancomycin 100% 100% 83 to 100%
TMP-SMX 14% 0% 17%

References

  1. ^  Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima. Antimicrobial Susceptibilities of Oral Isolates of Abiotrophia and Granulicatella According to the Consensus Guidelines for Fastidious Bacteria. Medicines. 2018;5(4):129. doi:10.3390/medicines5040129.