Dosing
- COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset
Renal Dosing
- eGFR ≥60 mL/min: no adjustment
- eGFR 30-59 mL/min: 150 mg/100 mg p.o. bid
- eGFR <30 mL/min: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days
- Dialysis: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days, given after dialysis on dialysis days
Hepatic Dosing
- Child-Pugh class C: contraindicated
