Eosinophilia

Differential Diagnosis

• Hematologic
  • Primary: eosinophilic leukemia, CMML, hypereosinophilic syndrome
  • Secondary: Non-Hodgkin lymphoma and Hodgkin lymphoma
• Infectious
  • Parasitic infections including Strongyloides stercoralis, hookworms, schistosomiasis, and scabies
  • Tropical pulmonary eosinophilia from filarial roundworms (Wuchereria bancrofti and Brugia species)
• Inflammatory
  • Eosinophilic pneumonia
  • Eosinophilic esophagitis
  • Eosinophilic myositis
  • Eosinophilic granulomatosis with polyantiitis (eGPA or Churg-Strauss)
• Endocrine
  • Addison disease
• Allergy
  • Atopy
  • Asthma
• Drugs
  • Drug reaction with eosinophilia and systemic symptoms (DRESS)

Investigations

• CBC
• Stool for ova and parasites (specifically for helminths rather than protozoa)
• Strongyloides serology, +/- Schistosoma serology
• ANCAs
• Review current medications