Post-acute sequalae of COVID-19
From IDWiki
Background
Epidemiology
- More common in patients with risk factors for severe COVID-19 disease
Clinical Manifestations
- Fatigue, dyspnea, chest pain, brain fog
- More common after severe disease
- At 2 months, about 2/3 had symptoms, with 33 to 37% having cough or dyspnea and 13 to 23% has dysgeusia or anosmia12
- Those with persistent symptoms were more likely to be aged 40 to 60 years and hospitalized
- At 6 months, 75% had at least one symptom3
- Fatigue or weakness (63%)
- Difficulty sleeping (26%)
- Hair loss (22%)
- Dysgeusia or anosmia (10%)
- A minority have changes to pulmonary function tests (8%) or chest x-ray (18%)4
- May have persistent lymphopenia, elevated ferritin, or elevated D-dimer
References
- ^ Vineet Chopra, Scott A. Flanders, Megan O'Malley, Anurag N. Malani, Hallie C. Prescott. Sixty-Day Outcomes Among Patients Hospitalized With COVID-19. Annals of Internal Medicine. 2020. doi:10.7326/m20-5661.
- ^ 10.1016/j.cmi.2020.09.052
- ^ Chaolin Huang, Lixue Huang, Yeming Wang, Xia Li, Lili Ren, Xiaoying Gu, Liang Kang, Li Guo, Min Liu, Xing Zhou, Jianfeng Luo, Zhenghui Huang, Shengjin Tu, Yue Zhao, Li Chen, Decui Xu, Yanping Li, Caihong Li, Lu Peng, Yong Li, Wuxiang Xie, Dan Cui, Lianhan Shang, Guohui Fan, Jiuyang Xu, Geng Wang, Ying Wang, Jingchuan Zhong, Chen Wang, Jianwei Wang, Dingyu Zhang, Bin Cao. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet. 2021;397(10270):220-232. doi:10.1016/s0140-6736(20)32656-8.
- a b Oscar Moreno-Pérez, Esperanza Merino, Jose-Manuel Leon-Ramirez, Mariano Andres, Jose Manuel Ramos, Juan Arenas-Jiménez, Santos Asensio, Rosa Sanchez, Paloma Ruiz-Torregrosa, Irene Galan, Alexander Scholz, Antonio Amo, Pilar Gonzålez-delaAleja, Vicente Boix, Joan Gil. Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. Journal of Infection. 2021. doi:10.1016/j.jinf.2021.01.004.
