Infection-associated glomerulonephritis
From IDWiki
- Term usually reserved to an immune-mediated glomerulonephritis associated with a bacterial infection
- Rarely caused by fungi, as well
| Type | Organisms | Timing | Clinical Characteristics | Laboratory Characteristics |
|---|---|---|---|---|
| post-streptococcal glomerulonephritis or post-infectious glomerulonephritis | Streptococcus pyogenes | 1-2 weeks after pharyngitis, 3-6 weeks after SSTI | abrupt onset with edema, subnephrotic proteinuria, often hypertension, more common in pediatrics | low C3, normal C4, rising ASO titres |
| Staphylococcus-associated glomerulonephritis | Staphylococcus aureus and Staphylococcus epidermidis | during acute infection | signs of underlying infection, AKI with microscopic hematuris and nephrotic-range proteinuria, may have rash (LCV); aggressive immunosuppression is contraindicated | low C3 in 50%, normal C4, sometimes positive ANCA with low titres |
| Glomerulonephritis from other infections | Gram-negative bacteria, Rickettsia, Chlamydia, Acinetobacter | subacute bacterial endocarditis, shunt nephritis, indwelling central venous catheter infections, and deep-seated visceral abscesses |
Investigations
- C3 and C4
- Proteinuria
