Nocardia species

Background

Microbiology

• Beaded Gram-positive partially acid-fast bacillus

Management

• Mild to moderate: TMP-SMX
  • Immunocompetent: 5-10 mg/kg split tid to qid
  • Immunocompromised: 15 mg/kg split tid to qid
• Severe: TMP-SMX plus either amikacin or imipenem
• Other antimicrobials include ceftriaxone, minocycline, and linezolid