Background
Mechanism of Action
- Binds to and inhibits PBP-2a
Spectrum of Activity
- Active against MRSA, Staphylococcus epidermidis, aerobic Gram-negative bacilli (similar to ceftriaxone)
- Low to moderate activity against Enterococcus species
- Not active against Pseudomonas species, ESBL-producers, or AmpC-producers
Pharmacokinetics and Pharmacodynamics
- Crosses in CSF adequately
Dosing
- SSTI: ceftaroline 600 mg IV q12h
- Pneumonia and bacteremia: ceftaroline 600 mg IV q8h
Safety
Adverse Drug Reactions
- Rash, eosinophilia, reversible neutropenia (20% when ≥3 weeks)
