Background
- Artemesinin compound indicated for the treatment of severe malaria
Dosing
- Adults and children ≥20 kg: 2.4 mg/kg at 0 hour, 12 hours, 24 hours, and 48 hours, followed by oral therapy
- Children <20 kg: 3.0 mg/kg at 0 hour, 12 hours, 24 hours, and 48 hours, followed by oral therapy
Safety
Post-Artesunate Delayed Hemolysis
- Likely the result from delayed clearance of previously-infected erythrocytes rather than toxic effect of the drug
- Recommend weekly CBC for at least 4 weeks following treatment, as well as clinical monitoring for signs and symptoms of anemia and jaundice
